Endocrine Abstracts

Medical plants believed to be safe and cost effective than synthetic hypoglycaemic agents play important roles in the management of diabetes mellitus in developing countries where resources are meagre. We have isolated triterpenes from Syzygium aromaticum as the bioactive compounds that possesses hypoglycaemic effects in experimental diabetes. However, the poor water solubility of triterpenes observed in oral administration has necess...

Medical plants believed to be safe and cost effective than synthetic hypoglycaemic agents play important roles in the management of diabetes mellitus in developing countries where resources are meagre. We have isolated triterpenes from Syzygium aromaticum as the bioactive compounds that possesses hypoglycaemic effects in experimental diabetes. However, the poor water solubility of triterpenes observed in oral administration has necess...

Investigations conducted in our laboratory have shown that transdermal delivery of insulin has several potential advantages over the conventional route. These pectin-insulin (PI)-containing dermal patches possess the ability to maintain sustained controlled release of insulin into the bloodstream of streptozotocin-induced diabetic rats with concomitant reduction of blood glucose levels. We have successfully formulated and optimized the concoction of the PI-containing dermal pa...